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The phrase "cotton-picking," sometimes spelled as "cotton-picken" or "cotton-pickin'" to signify a dialect, is used as an intensifier to describe something that is unpleasant or troublesome or of little value. The idiom arose in the southern U.S. states sometime during the 1700 among slaves.
Bugs Bunny may have popularized the phrase "Wait just a cotton-picking minute" and fixed it to our language. Here's an example in Bully for Bugs, 1953: "Just a cotton-pickin' minute, this don't look like the Coachella Valley to me!"